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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Guanine nucleotide-binding protein G(i) subunit alpha-2

UniprotKB/SwissProt ID: GNAI2_MOUSE (P08752)

Gene Name: Gnai2

Synonyms: Gnai-2

Organism: Mus musculus (Mouse).

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Cell membrane (By similarity). Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the mi

Network with metabolic pathway:
Kegg map ID Pathway Link
map05030Cocaine addiction
map04360Axon guidance
map04540Gap junction
map04670Leukocyte transendothelial migration
map04723Retrograde endocannabinoid signaling
map04724Glutamatergic synapse
map04725Cholinergic synapse
map04726Serotonergic synapse
map04727GABAergic synapse
map04728Dopaminergic synapse
map04730Long-term depression
map04971Gastric acid secretion
map05032Morphine addiction
map05133Pertussis
map05142Chagas disease (American trypanosomiasis)
map05145Toxoplasmosis
map04062Chemokine signaling pathway
map04530Tight junction
map04914Progesterone-mediated oocyte maturation
map04916Melanogenesis
map05034Alcoholism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001019
IPR001408
IPR011025

The S-nitrosylation sites of GNAI2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
166IHEDGYSEEE C RQYRAVVYSN HHCCCCCHHH H HHHHHHHHHH 3.58%MC0721278135in vitro
2140RLWADHGVQA C FGRSREYQLN HHHCCHHHHH H HHCCCCCCCC 1.76%MC0421278135in vitro
3326DTKEIYTHFT C ATDTKNVQFV CCCEEEEEEE E EECHHHHHHH 3.62%MC0421278135in vitro