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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: General transcription factor II-I repeat domain-containing protein 1

UniprotKB/SwissProt ID: GT2D1_MOUSE (Q9JI57)

Gene Name: Gtf2ird1

Synonyms: Ben

Organism: Mus musculus (Mouse).

Function: May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.

Network with metabolic pathway:
Kegg map ID Pathway Link
map03022Basal transcription factors
map05168Herpes simplex infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004212

The S-nitrosylation sites of GT2D1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1230ISLLPKGSRD C GLHGQASKVA HHHCCCHHHH H CCCCCCCCCC 6.41%MC0921278135in vitro