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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic

UniprotKB/SwissProt ID: HMCS1_RAT (P17425)

Gene Name: Hmgcs1

Synonyms: Hmgcs

Organism: Rattus norvegicus (Rat).

Function: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00072Synthesis and degradation of ketone bodies
map00280"Valine, leucine and isoleucine degradation"
map00650Butanoate metabolism
map00900Terpenoid backbone biosynthesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000590
IPR010122
IPR013528
IPR013746

The S-nitrosylation sites of HMCS1_RAT

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1417DLKSRLDSRT C VAPDVFAENM CCHHHHHHHE E ECHHHHHHHH 2.09%RC0422178444-
2417DLKSRLDSRT C VAPDVFAENM CCHHHHHHHE E ECHHHHHHHH 2.09%RC0419101475-