logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial

UniprotKB/SwissProt ID: HMCS2_HUMAN (P54868)

Gene Name: HMGCS2

Organism: Homo sapiens (Human).

Function: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD02580HMG-CoA synthase deficiency
Network with metabolic pathway:
Kegg map ID Pathway Link
map00072Synthesis and degradation of ketone bodies
map00280"Valine, leucine and isoleucine degradation"
map00650Butanoate metabolism
map00900Terpenoid backbone biosynthesis
map03320PPAR signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000590
IPR010122
IPR013528
IPR013746

The S-nitrosylation sites of HMCS2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1305LQYMIFHTPF C KMVQKSLARL CCEEEECCCC C HHHHHHHHHH 2.68%HC0825040305in vivo