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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Heterogeneous nuclear ribonucleoprotein H

UniprotKB/SwissProt ID: HNRH1_HUMAN (P31943)

Gene Name: HNRNPH1

Synonyms: HNRPH, HNRPH1

Organism: Homo sapiens (Human).

Function: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleoplasm.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000504
IPR012677
IPR012996

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2LXU NMR - A7-111Link

The S-nitrosylation sites of HNRH1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
134ADEVQRFFSD C KIQNGAQGIR HHHHHHHHHH C CCCCCEEEEE 3.97%HC1219483679in vivo
2122FVRLRGLPFG C SKEEIVQFFS EEEEECCCCC C CHHHHHHHHH 5.56%HC0519483679in vivo
3267SDRFGRDLNY C FSGMSDHRYG CCCCCCCCCC C CCCCCCCCCC 1.81%HC0722178444-
4267SDRFGRDLNY C FSGMSDHRYG CCCCCCCCCC C CCCCCCCCCC 1.81%HC072212679in vitro
5267SDRFGRDLNY C FSGMSDHRYG CCCCCCCCCC C CCCCCCCCCC 1.81%HC0719483679in vivo
6267SDRFGRDLNY C FSGMSDHRYG CCCCCCCCCC C CCCCCCCCCC 1.81%HC0720140087in vivo