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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Heterogeneous nuclear ribonucleoprotein L

UniprotKB/SwissProt ID: HNRPL_MOUSE (Q8R081)

Gene Name: Hnrnpl

Synonyms: Hnrpl

Organism: Mus musculus (Mouse).

Function: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

PDB :
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Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000504
IPR006536
IPR012677

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3S01 X-ray 2.15 A A376-586Link
3TYT X-ray 1.60 A A376-579Link

The S-nitrosylation sites of HNRPL_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1257SLNGADIYSG C CTLKIEYAKP CCCEECCCCC C CCCCCCCCCC 1.00%MC0322588120-
2258LNGADIYSGC C TLKIEYAKPT CCEECCCCCC C CCCCCCCCCC 5.95%MC1222588120-
3258LNGADIYSGC C TLKIEYAKPT CCEECCCCCC C CCCCCCCCCC 5.95%MC1220925432in vivo
4401MNCDRVFNVF C LYGNVEKVKF EECCHHHHHH H HHHHCCEEEC 2.20%MC0320925432in vivo
5449NFMFGQKMNV C VSKQPAIMPG CCCCCCCCCC C CCCCCCCCCC 2.13%MC1021278135in vitro
6578NGPYPYTLKL C FSTAQHAS--   2.12%MC0221278135in vitro