Protein Name: Haptoglobin
|
UniprotKB/SwissProt ID: HPT_HUMAN (P00738)
Gene Name: HP
Organism: Homo sapiens (Human).
Function: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted.
| |
|
Protein disease:
|
| Disease database |
Database Entry |
Disease information | | HPRD | 00772 | Anhaptoglobinemia | | HPRD | 00772 | Haptoglobin, alpha-1, fast-slow polymorphism | | HPRD | 00772 | Haptoglobin, alpha-2 |
|
Network with metabolic pathway:
|
|
Graphical Visualization of S-nitrosylation Sites:
|
| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
|
