logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Heat shock protein HSP 90-beta

UniprotKB/SwissProt ID: HS90B_MOUSE (P11499)

Gene Name: Hsp90ab1

Synonyms: Hsp84, Hsp84-1, Hspcb

Organism: Mus musculus (Mouse).

Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04612Antigen processing and presentation
map04621NOD-like receptor signaling pathway
map05215Prostate cancer
map04151PI3K-Akt signaling pathway
map04914Progesterone-mediated oocyte maturation
map05200Pathways in cancer
map04141Protein processing in endoplasmic reticulum
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001404
IPR003594

The S-nitrosylation sites of HS90B_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1366YVRRVFIMDS C DELIPEYLNF EEEEEEEECC H HHHCHHHHHH 4.03%MC0121278135in vitro
2366YVRRVFIMDS C DELIPEYLNF EEEEEEEECC H HHHCHHHHHH 4.03%MC0122865876in vivo
3521VYMTEPIDEY C VQQLKEFDGK EEECCCHHHH H HHHHHHCCCC 1.78%MC0421278135in vitro
4521VYMTEPIDEY C VQQLKEFDGK EEECCCHHHH H HHHHHHCCCC 1.78%MC0422865876in vivo
5564EESKAKFENL C KLMKEILDKK HHHHHHHHHH H HHHHHHCCCC 4.85%MC0124926564-
6564EESKAKFENL C KLMKEILDKK HHHHHHHHHH H HHHHHHCCCC 4.85%MC0121278135in vitro
7589TISNRLVSSP C CIVTSTYGWT EEEEEECCCC E EEEECCCCCC 2.39%MC1322865876in vivo
8590ISNRLVSSPC C IVTSTYGWTA EEEEECCCCE E EEECCCCCCH 2.96%MC0122865876in vivo