UniprotKB/SwissProt ID: HSP7C_HUMAN (P11142)
Gene Name: HSPA8
Synonyms: HSC70, HSP73, HSPA10
Organism: Homo sapiens (Human).
Function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Melanosome. Nucleus, nucleolus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
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