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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Peptidyl-tRNA hydrolase ICT1, mitochondrial

UniprotKB/SwissProt ID: ICT1_MOUSE (Q8R035)

Gene Name: Ict1

Synonyms: Mrpl58

Organism: Mus musculus (Mouse).

Function: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion (By similarity).

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000352

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1J26 NMR - A63-161Link

The S-nitrosylation sites of ICT1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
182IPLDRLSISY C RSSGPGGQNV CCCCCEEEEE E ECCCCCCCCC 2.44%MC1321278135in vitro