UniprotKB/SwissProt ID: IGSF8_MOUSE (Q8R366)
Gene Name: Igsf8
Synonyms: Ewi2, Kct4, Pgrl
Organism: Mus musculus (Mouse).
Function: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Single-pass membrane protein.
| |
|
