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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Inhibitor of nuclear factor kappa-B kinase subunit beta

UniprotKB/SwissProt ID: IKKB_HUMAN (O14920)

Gene Name: IKBKB

Synonyms: IKKB

Organism: Homo sapiens (Human).

Function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
OMIM603258INHIBITOR OF KAPPA LIGHT CHAIN GENE ENHANCER IN B CELLS, KINASE OF, BETA; IKBKB ;;NUCLEAR FA
Network with metabolic pathway:
Kegg map ID Pathway Link
map04930Type II diabetes mellitus
map05120Epithelial cell signaling in Helicobacter pylori infection
map05131Shigellosis
map05221Acute myeloid leukemia
map04064NF-kappa B signaling pathway
map04210Apoptosis
map04380Osteoclast differentiation
map04621NOD-like receptor signaling pathway
map04622RIG-I-like receptor signaling pathway
map04623Cytosolic DNA-sensing pathway
map04660T cell receptor signaling pathway
map04662B cell receptor signaling pathway
map04722Neurotrophin signaling pathway
map04920Adipocytokine signaling pathway
map05142Chagas disease (American trypanosomiasis)
map05145Toxoplasmosis
map05160Hepatitis C
map05212Pancreatic cancer
map05215Prostate cancer
map05220Chronic myeloid leukemia
map05222Small cell lung cancer
map04010MAPK signaling pathway
map04062Chemokine signaling pathway
map04150mTOR signaling pathway
map04151PI3K-Akt signaling pathway
map04620Toll-like receptor signaling pathway
map04910Insulin signaling pathway
map05161Hepatitis B
map05164Influenza A
map05166HTLV-I infection
map05168Herpes simplex infection
map05169Epstein-Barr virus infection
map05200Pathways in cancer
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000626
IPR000719
IPR001245
IPR008271
IPR011009
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3BRT X-ray 2.25 A A/C701-730Link
3BRV X-ray 2.20 A A/C701-745Link
4E3C X-ray 3.98 A A/B/C/D/E/F11-669Link
4KIK X-ray 2.83 A A/B2-664Link
The S-nitrosylation sites of IKKB_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1179YAKELDQGSL C TSFVGTLQYL EEEEECCCCE E EEEEECCCCC 2.99%HC0722178444-
2179YAKELDQGSL C TSFVGTLQYL EEEEECCCCE E EEEEECCCCC 2.99%HC0715184672-
3179YAKELDQGSL C TSFVGTLQYL EEEEECCCCE E EEEEECCCCC 2.99%HC0715688001-