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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Transcription factor AP-1

UniprotKB/SwissProt ID: JUN_HUMAN (P05412)

Gene Name: JUN

Organism: Homo sapiens (Human).

Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
KEGGH00020 Colorectal cancer
Network with metabolic pathway:
Kegg map ID Pathway Link
map05030Cocaine addiction
map05120Epithelial cell signaling in Helicobacter pylori infection
map04380Osteoclast differentiation
map04660T cell receptor signaling pathway
map04662B cell receptor signaling pathway
map04722Neurotrophin signaling pathway
map04912GnRH signaling pathway
map05031Amphetamine addiction
map05133Pertussis
map05140Leishmaniasis
map05142Chagas disease (American trypanosomiasis)
map05210Colorectal cancer
map05211Renal cell carcinoma
map05323Rheumatoid arthritis
map04010MAPK signaling pathway
map04012ErbB signaling pathway
map04310Wnt signaling pathway
map04510Focal adhesion
map04620Toll-like receptor signaling pathway
map05132Salmonella infection
map05161Hepatitis B
map05164Influenza A
map05166HTLV-I infection
map05168Herpes simplex infection
map05169Epstein-Barr virus infection
map05200Pathways in cancer
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002112
IPR004827
IPR005643
IPR008917
IPR011616
IPR015558

The S-nitrosylation sites of JUN_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1269RMRNRIAASK C RKRKLERIAR HHHHHHHHHH H HHHHHHHHHH 6.01%HC029108029-
2269RMRNRIAASK C RKRKLERIAR HHHHHHHHHH H HHHHHHHHHH 6.01%HC0223796488-
3320QKVMNHVNSG C QLMLTQQLQT HHHHHHHHCC C EECCCCCCCC 2.56%HC129108029-
4320QKVMNHVNSG C QLMLTQQLQT HHHHHHHHCC C EECCCCCCCC 2.56%HC1223796488-