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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Kynurenine--oxoglutarate transaminase 1

UniprotKB/SwissProt ID: KAT1_MOUSE (Q8BTY1)

Gene Name: Ccbl1

Synonyms: Kat

Organism: Mus musculus (Mouse).

Function: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00380Tryptophan metabolism
map00450Selenocompound metabolism
map05204Chemical carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001176
IPR004839
IPR015421
IPR015424

The S-nitrosylation sites of KAT1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1280RTVHQNSIFH C PTQAQAAVAQ HHHHCCCCCC C CHHHHHHHHH 2.44%MC0122865876in vivo
2291PTQAQAAVAQ C FEREQQHFGQ CHHHHHHHHH H HHCHHHHHHH 2.49%MC0522865876in vivo