Protein Name: Calcium/calmodulin-dependent protein kinase type II subunit gamma
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UniprotKB/SwissProt ID: KCC2G_HUMAN (Q13555)
Gene Name: CAMK2G
Synonyms: CAMK, CAMK-II, CAMKG
Organism: Homo sapiens (Human).
Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (Probable).
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 602123 | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II-GAMMA; CAMK2G ;;CaM KINASE II GAMMA SUBUNIT;; |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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