Protein Name: Potassium voltage-gated channel subfamily A member 5
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UniprotKB/SwissProt ID: KCNA5_HUMAN (P22460)
Gene Name: KCNA5
Organism: Homo sapiens (Human).
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Multi-pass membrane protein.
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | KEGG | H00731 | Atrial fibrillation | | OMIM | 176267 | POTASSIUM CHANNEL, VOLTAGE-GATED, SHAKER-RELATED SUBFAMILY, MEMBER 5; KCNA5 ;;POTASSIUM CHAN | | OMIM | 612240 | ATRIAL FIBRILLATION, FAMILIAL, 7; ATFB7 |
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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