UniprotKB/SwissProt ID: KDM5C_HUMAN (P41229)
Gene Name: KDM5C
Synonyms: DXS1272E, JARID1C, SMCX, XE169
Organism: Homo sapiens (Human).
Function: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
|
PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. ) |
