Protein Name: Lysine-specific demethylase 6A
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UniprotKB/SwissProt ID: KDM6A_MOUSE (O70546)
Gene Name: Kdm6a
Synonyms: Utx
Organism: Mus musculus (Mouse).
Function: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus (Potential).
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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