Protein Name: Legumain
|
UniprotKB/SwissProt ID: LGMN_HUMAN (Q99538)
Gene Name: LGMN
Synonyms: PRSC1
Organism: Homo sapiens (Human).
Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lysosome (By similarity).
| |
|
Network with metabolic pathway:
|
|
Graphical Visualization of S-nitrosylation Sites:
|
| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
|
