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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Leucine-rich repeat-containing protein 59

UniprotKB/SwissProt ID: LRC59_MOUSE (Q922Q8)

Gene Name: Lrrc59

Organism: Mus musculus (Mouse).

Function: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). Nucleus envelope (By similarity). Note=Localization in the nuclear envelope depends upon the n

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001611

The S-nitrosylation sites of LRC59_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
148LPKATVLDLS C NKLSTLPSDF CCCCCEEECC C CCCCCCCHHH 7.28%MC0620925432in vivo
259NKLSTLPSDF C GLTHLVKLDL CCCCCCCHHH C CCCCCCEEEC 5.39%MC0520925432in vivo
3137VAGDCLDEKQ C KQCANKVLQH HHHHCCHHHH H HHHHHHHHHC 4.94%MC0220925432in vivo
4140DCLDEKQCKQ C ANKVLQHMKA HCCHHHHHHH H HHHHHHCCCC 2.49%MC0320925432in vivo