UniprotKB/SwissProt ID: MACD1_HUMAN (Q9BQ69)
Gene Name: MACROD1
Synonyms: LRP16
Organism: Homo sapiens (Human).
Function: Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins.
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PDB :
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