UniprotKB/SwissProt ID: MAP2_MOUSE (O08663)
Gene Name: Metap2
Synonyms: Mnpep, P67eif2
Organism: Mus musculus (Mouse).
Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (By similarity). Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Note=About 30% of expressed METAP2 associates with polysomes (By similarity).
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