Protein Name: Mini-chromosome maintenance complex-binding protein
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UniprotKB/SwissProt ID: MCMBP_HUMAN (Q9BTE3)
Gene Name: MCMBP
Synonyms: C10orf119
Organism: Homo sapiens (Human).
Function: Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chro
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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