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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Trans-2-enoyl-CoA reductase, mitochondrial

UniprotKB/SwissProt ID: MECR_MOUSE (Q9DCS3)

Gene Name: Mecr

Synonyms: Nrbf1

Organism: Mus musculus (Mouse).

Function: Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2- decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00062Fatty acid elongation
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002085
IPR011032
IPR013149
IPR013154

The S-nitrosylation sites of MECR_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1169QSAATLGVNP C TAYRMLVDFE HHHHHHCCHH H HHHHHHHHHC 2.61%MC0721278135in vitro
2263DLPLPRLALN C VGGKSSTELL CCCCEEEEEE C CCHHHHHHHH 2.90%MC0721278135in vitro
3345IRQGRLTAPS C SEVPLQGYQQ HHCCCCCCCC E EEECHHHHHH 3.81%MC0821278135in vitro