UniprotKB/SwissProt ID: MILK2_MOUSE (Q3TN34)
Gene Name: Micall2
Synonyms: Jrab
Organism: Mus musculus (Mouse).
Function: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Recycling endosome. Cell projection (By similarity). Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
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