Protein Name: Myelin protein zero-like protein 1
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UniprotKB/SwissProt ID: MPZL1_HUMAN (O95297)
Gene Name: MPZL1
Synonyms: PZR
Organism: Homo sapiens (Human).
Function: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Single-pass type I membrane protein (Potential).
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 604376 | MYELIN PROTEIN ZERO-LIKE 1; MPZL1 ;;PROTEIN ZERO-RELATED; PZR |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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