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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Metallothionein-1

UniprotKB/SwissProt ID: MT1_MOUSE (P02802)

Gene Name: Mt1

Organism: Mus musculus (Mouse).

Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04978Mineral absorption
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000006
IPR003019

The S-nitrosylation sites of MT1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
133NCKCTSCKKS C CSCCPVGCSK CCCCCCCCCC C CCCCCCCCHH 2.45%MC0924895380-
234CKCTSCKKSC C SCCPVGCSKC CCCCCCCCCC C CCCCCCCHHH 4.50%MC0324895380-
336CTSCKKSCCS C CPVGCSKCAQ CCCCCCCCCC C CCCCCHHHCC 1.57%MC0524895380-
437TSCKKSCCSC C PVGCSKCAQG CCCCCCCCCC C CCCCHHHCCC 1.43%MC0124895380-
541KSCCSCCPVG C SKCAQGCVCK CCCCCCCCCC C HHHCCCCEEC 3.41%MC0624895380-
6131GVSQTPSYLS C KSEVEVKKIF   %MC0522178444-
7131GVSQTPSYLS C KSEVEVKKIF   %MC0520837516in vivo
8217KAGASIVGVN C HFDPSVSLQT   %MC1322178444-
9217KAGASIVGVN C HFDPSVSLQT   %MC1320837516
(Cys267)
in vivo
10256SQPLAYHTPD C GKQGFIDLPE   %MC0622178444-
11256SQPLAYHTPD C GKQGFIDLPE   %MC0620837516in vivo
12299YNLGVRYIGG C CGFEPYHIRA   %MC0322178444-
13299YNLGVRYIGG C CGFEPYHIRA   %MC0320837516in vivo
14300NLGVRYIGGC C GFEPYHIRAI   %MC0222178444-
15300NLGVRYIGGC C GFEPYHIRAI   %MC0220837516in vivo