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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Myosin-6

UniprotKB/SwissProt ID: MYH6_MOUSE (Q02566)

Gene Name: Myh6

Synonyms: Myhca

Organism: Mus musculus (Mouse).

Function: Muscle contraction.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04260Cardiac muscle contraction
map05410Hypertrophic cardiomyopathy (HCM)
map05414Dilated cardiomyopathy
map05416Viral myocarditis
map04530Tight junction
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000048
IPR001609
IPR002928
IPR004009
IPR015650
The S-nitrosylation sites of MYH6_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
137QTRPFDIRTE C FVPDDKEEYV HCCCCCCCCE E ECCCCCCCEE 4.05%MC0221278135in vitro
237QTRPFDIRTE C FVPDDKEEYV HCCCCCCCCE E ECCCCCCCEE 4.05%MC0222865876in vivo
3401LNSADLLKGL C HPRVKVGNEY CCHHHHHHHH C CCEEEECCEE 5.91%MC0422865876in vivo
4674LKTTHPHFVR C IIPNERKAPG HHCCCCCEEE E EECCCCCCCC 2.51%MC0222865876in vivo
5697DNPLVMHQLR C NGVLEGIRIC CHHHHHHHHH H HHHHHHHHHH 7.65%MC1021278135in vitro
6697DNPLVMHQLR C NGVLEGIRIC CHHHHHHHHH H HHHHHHHHHH 7.65%MC1022865876in vivo
7907QDNLNDAEER C DQLIKNKIQL HHHHHHHHHH H HHHHHHHHHH 4.41%MC0421278135in vitro
8907QDNLNDAEER C DQLIKNKIQL HHHHHHHHHH H HHHHHHHHHH 4.41%MC0422865876in vivo
9949TAKKRKLEDE C SELKKDIDDL HHHHHHHHHH H HHHHHHHHHH 6.23%MC0121278135in vitro
10949TAKKRKLEDE C SELKKDIDDL HHHHHHHHHH H HHHHHHHHHH 6.23%MC0122865876in vivo
111342AHALQSSRHD C DLLREQYEEE HHHHHHHHHH H HHHHHHHHHH 3.03%MC0721278135in vitro
121342AHALQSSRHD C DLLREQYEEE HHHHHHHHHH H HHHHHHHHHH 3.03%MC0722865876in vivo
131413EEAVEAVNAK C SSLEKTKHRL HHHHHHHHHH H HHHHHHHHHH 2.87%MC0321278135in vitro
141413EEAVEAVNAK C SSLEKTKHRL HHHHHHHHHH H HHHHHHHHHH 2.87%MC0322865876in vivo
151750QTEVEEAVQE C RNAEEKAKKA HHHHHHHHHH H HHHHHHHHHH 1.96%MC0221278135in vitro
161750QTEVEEAVQE C RNAEEKAKKA HHHHHHHHHH H HHHHHHHHHH 1.96%MC0222865876in vivo