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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Bifunctional protein NCOAT

UniprotKB/SwissProt ID: NCOAT_HUMAN (O60502)

Gene Name: MGEA5

Synonyms: HEXC, KIAA0679, MEA5

Organism: Homo sapiens (Human).

Function: Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl- beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform 3: Nucleus. Isoform 1: Cytoplasm.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR011496

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2YDQ X-ray 2.60 A T402-408Link

The S-nitrosylation sites of NCOAT_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1896RILEFYSKLG C FEIAKMEGFP HHHHHHHHCC C EEEHHHCCCC 3.92%HC0419483679in vivo