Protein Name: Nitric oxide synthase, endothelial
|UniprotKB/SwissProt ID: NOS3_HUMAN (P29474)|
Gene Name: NOS3
Organism: Homo sapiens (Human).
Function: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
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|OMIM||104300||ALZHEIMER DISEASE; AD ;;PRESENILE AND SENILE DEMENTIA ALZHEIMER DISEASE, FAMILIAL, 1, INCLUD|
|OMIM||145500||HYPERTENSION, ESSENTIAL ;;EHT|
|OMIM||163729||NITRIC OXIDE SYNTHASE 3; NOS3 ;;NITRIC OXIDE SYNTHASE, ENDOTHELIAL; ENOS CORONARY ARTERY SPA|
|OMIM||601367||STROKE, ISCHEMIC ;;CEREBROVASCULAR ACCIDENT;; CEREBRAL INFARCTION|
|HPRD||01224||Coronary spasms, susceptibility to|
|Network with metabolic pathway:|
|Graphical Visualization of S-nitrosylation Sites:|
|Overview of Protein S-nitrosylation Sites with Functional and Structural Information|