Protein Name: Probable 8-oxo-dGTP diphosphatase NUDT15
|
UniprotKB/SwissProt ID: NUD15_MOUSE (Q8BG93)
Gene Name: Nudt15
Synonyms: Mth2
Organism: Mus musculus (Mouse).
Function: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
| |
|
Graphical Visualization of S-nitrosylation Sites:
|
| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
|
