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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hydrogen peroxide-inducible genes activator

UniprotKB/SwissProt ID: OXYR_ECOLI (P0ACQ4)

Gene Name: oxyR

Synonyms: momR, mor

Organism: Escherichia coli (strain K12).

Function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000847
IPR005119
IPR011991

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1I69 X-ray 2.70 A A/B87-305Link
1I6A X-ray 2.30 A A87-305Link

The S-nitrosylation sites of OXYR_ECOLI

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1199EKLLMLEDGH C LRDQAMGFCF CCEEEECCCC C HHHHHHHHHH 4.00%EC0122178444-
2199EKLLMLEDGH C LRDQAMGFCF CCEEEECCCC C HHHHHHHHHH 4.00%EC0112015987in vitro
3199EKLLMLEDGH C LRDQAMGFCF CCEEEECCCC C HHHHHHHHHH 4.00%EC0114993439-
4199EKLLMLEDGH C LRDQAMGFCF CCEEEECCCC C HHHHHHHHHH 4.00%EC0115688001-