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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cytosolic phospholipase A2

UniprotKB/SwissProt ID: PA24A_HUMAN (P47712)

Gene Name: PLA2G4A

Synonyms: CPLA2, PLA2G4

Organism: Homo sapiens (Human).

Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00564Glycerophospholipid metabolism
map00565Ether lipid metabolism
map00590Arachidonic acid metabolism
map00591Linoleic acid metabolism
map00592alpha-Linolenic acid metabolism
map04664Fc epsilon RI signaling pathway
map04370VEGF signaling pathway
map04666Fc gamma R-mediated phagocytosis
map04724Glutamatergic synapse
map04726Serotonergic synapse
map04730Long-term depression
map04912GnRH signaling pathway
map04010MAPK signaling pathway
map04270Vascular smooth muscle contraction
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000008
IPR000209
IPR002642
IPR008162
IPR008973

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1BCI NMR - A1-138Link
1CJY X-ray 2.50 A A/B1-749Link
1RLW X-ray 2.40 A A17-138Link

The S-nitrosylation sites of PA24A_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1151CPDLRFSMAL C DQEKTFRQQR CCCCCCCCCC C HHHHHHHHHH 3.54%HC1022178444-
2151CPDLRFSMAL C DQEKTFRQQR CCCCCCCCCC C HHHHHHHHHH 3.54%HC1018029351-