UniprotKB/SwissProt ID: PAPS1_HUMAN (O43252)
Gene Name: PAPSS1
Synonyms: ATPSK1, PAPSS
Organism: Homo sapiens (Human).
Function: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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PDB :
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