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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Sister chromatid cohesion protein PDS5 homolog A

UniprotKB/SwissProt ID: PDS5A_HUMAN (Q29RF7)

Gene Name: PDS5A

Synonyms: KIAA0648, PDS5

Organism: Homo sapiens (Human).

Function: Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Note=Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

The S-nitrosylation sites of PDS5A_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
11079SKTNEKLYTV C DVALCVINSK   2.41%HC1219483679in vivo
21084KLYTVCDVAL C VINSKSALCN   1.76%HC0719483679in vivo