UniprotKB/SwissProt ID: PERM1_MOUSE (Q149B8)
Gene Name: Perm1
Organism: Mus musculus (Mouse).
Function: Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Shows a nuclear localization in the presence of PPARGC1A.
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