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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein phosphatase methylesterase 1

UniprotKB/SwissProt ID: PPME1_HUMAN (Q9Y570)

Gene Name: PPME1

Synonyms: PME1

Organism: Homo sapiens (Human).

Function: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000073
IPR008262

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3C5V X-ray 2.00 A A39-386Link
3C5W X-ray 2.80 A P39-386Link

The S-nitrosylation sites of PPME1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1312FRGLSNLFLS C PIPKLLLLAG HCCCCCCCCC C CCCEEEEEEC 3.73%HC1219483679in vivo