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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Peroxiredoxin-5, mitochondrial

UniprotKB/SwissProt ID: PRDX5_HUMAN (P30044)

Gene Name: PRDX5

Synonyms: ACR1

Organism: Homo sapiens (Human).

Function: Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04146Peroxisome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR012335
IPR012336
IPR013740

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1H4O X-ray 1.95 A A/B/C/D/E/F/G/H54-214Link
1HD2 X-ray 1.50 A A54-214Link
1OC3 X-ray 2.00 A A/B/C54-214Link
1URM X-ray 1.70 A A54-214Link
2VL2 X-ray 1.92 A A/B/C54-214Link
2VL3 X-ray 1.83 A A/B/C54-214Link
2VL9 X-ray 2.70 A A/B/C/D54-214Link
3MNG X-ray 1.45 A A54-214Link

The S-nitrosylation sites of PRDX5_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1100FGVPGAFTPG C SKTHLPGFVE EEECCCCCCC C CHHHHHHHHH 3.87%HC0522178444-
2100FGVPGAFTPG C SKTHLPGFVE EEECCCCCCC C CHHHHHHHHH 3.87%HC0520140087in vivo