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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Peroxiredoxin-6

UniprotKB/SwissProt ID: PRDX6_MOUSE (O08709)

Gene Name: Prdx6

Synonyms: Aop2, Ltw4, Prdx5

Organism: Mus musculus (Mouse).

Function: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Lysosome (By similarity). Cytoplasmic vesicle (By similarity). Note=Also found in lung secretory organelles (By similarity).

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000866
IPR012335
IPR012336
The S-nitrosylation sites of PRDX6_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
147FSHPRDFTPV C TTELGRAAKL EEECCCCCCC C CHHHHHHHHH 4.03%MC0222178444-
247FSHPRDFTPV C TTELGRAAKL EEECCCCCCC C CHHHHHHHHH 4.03%MC0222588120-
347FSHPRDFTPV C TTELGRAAKL EEECCCCCCC C CHHHHHHHHH 4.03%MC0224895380-
447FSHPRDFTPV C TTELGRAAKL EEECCCCCCC C CHHHHHHHHH 4.03%MC0219101475-
547FSHPRDFTPV C TTELGRAAKL EEECCCCCCC C CHHHHHHHHH 4.03%MC0221278135in vitro
647FSHPRDFTPV C TTELGRAAKL EEECCCCCCC C CHHHHHHHHH 4.03%MC0220837516in vivo
7201PTLSEEEAKQ C FPKGVFTKEL CCCCHHHHHH H HCCCCEEEEC 6.59%MC0921278135in vitro