Protein Name: Pre-mRNA-processing factor 19
|
UniprotKB/SwissProt ID: PRP19_MOUSE (Q99KP6)
Gene Name: Prpf19
Synonyms: Prp19, Snev
Organism: Mus musculus (Mouse).
Function: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus (By similarity). Nucleus, nucleoplasm (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Note=Nucleoplasmic in interphase cells. Irregularly distributed in anaphase cells. In prophase cells, uniformly distributed, but not associat
| |
|
Network with metabolic pathway:
|
|
Graphical Visualization of S-nitrosylation Sites:
|
| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
|
