logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: 26S proteasome non-ATPase regulatory subunit 11

UniprotKB/SwissProt ID: PSD11_HUMAN (O00231)

Gene Name: PSMD11

Organism: Homo sapiens (Human).

Function: Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity). Cytoplasm, cytosol (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map03050Proteasome
map05169Epstein-Barr virus infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000717
IPR011991
IPR013143

The S-nitrosylation sites of PSD11_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1202SARTTANAIY C PPKLQATLDM HHHHHCCCCC C CHHHHHHHHH 3.67%HC062212679in vitro
2202SARTTANAIY C PPKLQATLDM HHHHHCCCCC C CHHHHHHHHH 3.67%HC0619483679in vivo
3289YAGRQTEALK C VAQASKNRSL HCCCHHHHHH H HHHHHCCCCH 2.97%HC0119483679in vivo