Protein Name: 26S proteasome non-ATPase regulatory subunit 14
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UniprotKB/SwissProt ID: PSDE_HUMAN (O00487)
Gene Name: PSMD14
Synonyms: POH1
Organism: Homo sapiens (Human).
Function: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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