UniprotKB/SwissProt ID: PSIP1_HUMAN (O75475)
Gene Name: PSIP1
Synonyms: DFS70, LEDGF, PSIP2
Organism: Homo sapiens (Human).
Function: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=Remains chromatin-associated throughout the cell cycle.
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PDB :
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