Protein Name: Ras-related protein Rab-1A
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UniprotKB/SwissProt ID: RAB1A_MOUSE (P62821)
Gene Name: Rab1A
Synonyms: Rab1
Organism: Mus musculus (Mouse).
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus (By similarity). Endoplasmic reticulum (By similarity). Early endosome (By similarity). Cytoplasm, cytosol (By similarity). Membrane (By similarity). Melanosome. Note=Alternates between membrane-associated and cytosolic forms (By similari
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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