Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.
Function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome (By similarity). Cytoplasm. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (By similarity). Found in the ruffled border (a late end
Network with metabolic pathway:
Kegg map ID
Pathway
Link
map04664
Fc epsilon RI signaling pathway
map05014
Amyotrophic lateral sclerosis (ALS)
map04360
Axon guidance
map04370
VEGF signaling pathway
map04380
Osteoclast differentiation
map04520
Adherens junction
map04650
Natural killer cell mediated cytotoxicity
map04662
B cell receptor signaling pathway
map04666
Fc gamma R-mediated phagocytosis
map04670
Leukocyte transendothelial migration
map04722
Neurotrophin signaling pathway
map04972
Pancreatic secretion
map05100
Bacterial invasion of epithelial cells
map05210
Colorectal cancer
map05211
Renal cell carcinoma
map05212
Pancreatic cancer
map05416
Viral myocarditis
map04010
MAPK signaling pathway
map04062
Chemokine signaling pathway
map04145
Phagosome
map04151
PI3K-Akt signaling pathway
map04310
Wnt signaling pathway
map04510
Focal adhesion
map04620
Toll-like receptor signaling pathway
map04810
Regulation of actin cytoskeleton
map05132
Salmonella infection
map05200
Pathways in cancer
map05203
Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information