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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ran GTPase-activating protein 1

UniprotKB/SwissProt ID: RAGP1_HUMAN (P46060)

Gene Name: RANGAP1

Synonyms: KIAA1835, SD

Organism: Homo sapiens (Human).

Function: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore (By similarity). Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=Cytoplasmic during interphase. Targeted to the nuclear rim after

PDB :
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Protein disease:
Disease database Database Entry Disease information
OMIM602362GTPase-ACTIVATING PROTEIN, RAN, 1; RANGAP1 ;;RAN GTPase-ACTIVATING PROTEIN 1
Network with metabolic pathway:
Kegg map ID Pathway Link
map03013RNA transport
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1Z5S X-ray 3.01 A C418-587Link
2GRN X-ray 1.80 A B419-587Link
2GRO X-ray 1.70 A B419-587Link
2GRP X-ray 2.05 A B419-587Link
2GRQ X-ray 1.70 A B419-587Link
2GRR X-ray 1.30 A B419-587Link
2IO2 X-ray 2.90 A C418-587Link
2IO3 X-ray 3.20 A C418-587Link
2IY0 X-ray 2.77 A C432-587Link
3UIN X-ray 2.60 A C419-587Link
3UIO X-ray 2.60 A C419-587Link
3UIP X-ray 2.29 A C419-587Link

The S-nitrosylation sites of RAGP1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1169GKILAAALTE C HRKSSAQGKP   2.95%HC0519483679in vivo