Protein Name: Ras-related protein Rap-1A
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UniprotKB/SwissProt ID: RAP1A_MOUSE (P62835)
Gene Name: Rap1a
Synonyms: Krev-1
Organism: Mus musculus (Mouse).
Function: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Lipid-anchor (By similarity). Cell junction. Cytoplasm (By similarity). Cytoplasm, perinuclear region (By similarity). Early endosome (By similarity). Late endosome (By similarity). Note=Recruited from early endosome to late endosome compa
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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