Protein Name: Ras-related protein Rap-1b
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UniprotKB/SwissProt ID: RAP1B_MOUSE (Q99JI6)
Gene Name: Rap1b
Organism: Mus musculus (Mouse).
Function: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane (By similarity). Cytoplasm, cytosol (By similarity). Cell junction (By similarity). Note=May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction (By similarity).
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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