Protein Name: E3 SUMO-protein ligase RanBP2
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UniprotKB/SwissProt ID: RBP2_HUMAN (P49792)
Gene Name: RANBP2
Synonyms: NUP358
Organism: Homo sapiens (Human).
Function: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Detected in diffuse and discrete intranuclear foci. Cytoplasmic filaments.
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 601181 | RAN-BINDING PROTEIN 2; RANBP2 ;;NUP358 | | OMIM | 608033 | ENCEPHALOPATHY, ACUTE NECROTIZING 1, SUSCEPTIBILITY TO; ANE1 |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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