UniprotKB/SwissProt ID: RCC1_HUMAN (P18754)
Gene Name: RCC1
Synonyms: CHC1
Organism: Homo sapiens (Human).
Function: Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Becomes dispersed throughout the cytoplasm during mitosis.
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PDB :
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